Titlebook: Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research; M. R. Waterman,M. Hildebrand Conference proceedings 1994 Springe

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Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?,micals. Studies over the past 20 years have provided evidence that cytochromes P450 occur in many different forms (isoforms or isozymes) which differ in spectral, chemical, and immunological properties and have different substrate affinities. These isozymes also differ in their regulation and tissue

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Metabolic Activation of Anticancer Oxazaphosphorines by Cytochrome P450s: Development of a Model foand are widely used in cancer chemotherapy (reviewed by Sladek 1988). Cyclophosphamide and ifosphamide are therapeutically inactive prodrugs that must be activated by liver metabolism following administration to cancer patients. Early studies implicated liver cytochrome P450 as the catalyst of cyclo

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The Use of Bacteria for Cytochrome P450 Expression,calization of the approximately 200 forms of human P450, (b) characterization of the enzymatic properties of these enzymes and thus their relatedness regarding overlapping substrate metabolism, and (c) determination of the structure-function relationships in human P450s. Over the past decade revolut

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Human Cells as an Expression System for Cytochromes P450,athways of metabolism can influence the safety and/or efficacy of a drug or drug candidate. Because of the central role of cytochrome P450s in drug metabolism and also carcinogenesis, considerable effort has been devoted by many laboratories to the development of model systems to study human P450 me

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The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism,0 (P450) enzymes were reported more than 50 years ago (Mueller and Miller 1953; Brodie et al. 1958), and they are now recognized to be the major catalysts involved in the metabolism of drugs, steroids, carcinogens, pesticides, and pollutants (see entire January 1992 issue of .). There has been consi

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Strategies for the Use of Single Cytochrome P450 Enzymes in Drug Research and Future Prospects,red to develop analytical tools. In this context, cell culture technology has made a very important contribution to the area of in vitro systems (Doehmer 1993). The combination of gene technology and cell culture technology has provided new opportunities for studying drug metabolism related problems

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