Titlebook: Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research; M. R. Waterman,M. Hildebrand Conference proceedings 1994 Springe

时代

Ernst Schering Foundation Symposium Proceedingshttp://image.papertrans.cn/b/image/163405.jpg

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Conference proceedings 20071st editiontabolism and also carcinogenesis, considerable effort has been devoted by many laboratories to the development of model systems to study human P450 metabolism (reviews: Gonzalez 1988; Guengerich 1988; Gonzalez et al. 1991; Langenbach et al. 1992).

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Pests of Logs, Lumber, and Forest Products,bital or prednisone (Faber et al. 1974; Sladek 1972), agents that are known to induce liver P450 enzymes both in humans and in rats (Pichard et al. 1992). More recent studies carried out in this laboratory have validated this conclusion using purified and cDNA-expressed P450 enzymes, as summarized below (Chang et al. 1993; Clarke and Waxman 1989).

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Cytochrome P450 in Human Drug Metabolism: How Much Is Predictable?,rganism. Close to 30 human cytochrome P450 genes have now been characterized. The multiplicity of P450 isozymes explains in part the literally thousands of substrates known to be metabolized by this system (for review, see Nelson et al. 1993).

分开如此和谐

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Regulation of Xenobiotic-Metabolizing Cytochromes P450,tochrome P450” on the basis of a Soret absorbance band when reduced and complexed with carbon monoxide (Omura and Sato 1961, 1964a,b). The latter property is due to the presence of a noncovalently bound heme in the form of protoporphyrin IX.