Titlebook: Arthritis Research; Methods and Protocol Shunichi Shiozawa Book 2014Latest edition Springer Science+Business Media New York 2014 autoimmune

钉牢

Cumulus

丰富

衍生

LEVY

Intravital Multiphoton Microscopy for Dissecting Cellular Dynamics in Arthritic Inflammation and Boritical roles not only in normal bone homeostasis (remodeling) but also in the pathogenesis of bone-destructive disorders such as osteoporosis and rheumatoid arthritis. However, how the activity of mature osteoclasts is regulated in vivo remains unclear. To answer this question, we recently develope

cluster

Monitoring Multifunctionality of Immune-Exhausted CD8 T Cells in Cancer Patients,es not always imply that cancers and/or pathogens are efficiently eliminated in the body. Concerning this point, the recent studies suggest the concept of immune exhaustion of CD8 T cells, characterized by their decreased production of IL-2, TNFα, and IFNγ even after antigen stimulation. Thus, conti

LAPSE

Armory

Principles for the Use of In Vivo Transgene Techniques: Overview and an Introductory Practical Guidtional transgenic mice have the limitation that constitutive expression of a transgene from the embryonic stage may affect the normal development of the mice or cause compensating effects. To overcome these disadvantages, tetracycline-controlled transgenic mice, which can express target gene product

Cholesterol

Unraveling Autoimmunity with the Adoptive Transfer of T Cells from TCR-Transgenic Mice,ire. These mice have been extensively used as tools to circumvent the low precursor frequency of naturally occurring endogenous T cells. As such, they have been valuable to study pathways of T-cell development in the thymus. In addition, these mice can also be considered as a valuable source of naiv

Thyroid-Gland

In Vivo Cell Transfer Assay to Detect Autoreactive T Cell Subsets,are less widely employed. In our studies on systemic lupus erythematosus (SLE), we have identified a novel T cell subtype termed “autoantibody-inducing CD4 T cells” (.CD4 T cell) that is responsible for the development of autoimmunity. In order to identify and isolate these cells, we developed a new