Titlebook: Arachidonic Acid in Cell Signaling; Daniele Piomelli Book 1996 Springer Science+Business Media Dordrecht 1996 biochemistry.cell.chemistry.

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https://doi.org/10.1007/978-3-662-05807-7biochemistry; cell; chemistry; pharmacology; signal transduction

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978-3-662-05809-1Springer Science+Business Media Dordrecht 1996

WAX

The Arachidonic Acid Cascade,ormational molecules. These signals are essential for the survival of free-living cells and for coordinating the complex needs of multicellular organisms: as adaptive demands and cell functions changed during evolution, they underwent dramatic transformations in their modes of action, and were calle

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Before Metabolism: Arachidonate as an Intracellular Second Messenger,1950s, the set of experimental criteria originally proposed by Earl Sutherland to define a second messenger molecule are still applicable today. These criteria, listed in Table 3.1, are based on the definition of a second messenger as an endogenous molecule whose role is to transduce within a target

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Arachidonate Metabolism,ies of the enzymatic systems involved in these reactions. As this task will oblige us to go into a considerable amount of factual detail, it may be helpful to begin with a general overview of arachidonate metabolism, whose landmarks are illustrated in Figure 4.1.

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The Eicosanoids in Cellular Signaling,sponsible for translating receptor occupancy into cellular responses. For example, the binding of dopamine to D.-type receptors on neurons stimulates the activity of the enzyme adenylate cyclase, which catalyzes the conversion of ATP into cyclic AMP. This second messenger, in turn, binds to and acti

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Biosynthesis, Storage and Mobilization of Arachidonic Acid, exclusively found in the plasma membrane; a set of enzymes that synthesize this precursor; and a stimulus-activated phos-pholipase that hydrolyzes it, producing one or more metabolites with distinct biological effects.

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