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Titlebook: Applied Statistics in Biomedicine and Clinical Trials Design; Selected Papers from Zhen Chen,Aiyi Liu,Yi Tsong Conference proceedings 2015

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Issues in the Use of Existing Data: As Controls in Pre-Market Comparative Clinical Studies clinical studies also play an important role in the evaluation in both premarket and postmarket settings. Such observational comparative studies could be concurrent or nonconcurrent depending on the timing when patients get treated. A nonconcurrent control group could be formed from patients with e
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The Effect of Substrate Concentration,a control regimen. Traditionally, the non-inferiority hypothesis is tested using frequentist methods, e.g., comparing the lower bound of 95 % confidence interval with a pre-specified non-inferiority margin. The analyses are often based on maximum likelihood methods. Recently, Bayesian approaches hav
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