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Titlebook: Applied Statistics in Biomedicine and Clinical Trials Design; Selected Papers from Zhen Chen,Aiyi Liu,Yi Tsong Conference proceedings 2015

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Jaydeep Yadav,Ken Korzekwa,Swati Nagar of errors are controlled, such as the error of wrongly approving an ineffective drug and the error of labeling false information. With the collective evidence approach, the need of MAPs in individual studies is debated when multiple studies are available.
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https://doi.org/10.1007/978-1-62703-758-7ectation of the magnitude of regional differences and the statutory requirements in the USA. Examples are presented to illustrate the design and analysis based on our proposed procedure. Using the proposed two-tier procedure with an upfront explicit decision tree can increase the predictability and transparency of the regulatory decision making.
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Estimation of ROC Curve with Multiple Types of Missing Gold Standardmulation studies to compare the performance of the proposed method and the existing approaches in the literature. This methodology is motivated from and applied to a study in Alzheimer’s disease (AD), where two reasons of missingness are modeled separately.
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A Two-Tier Procedure for Designing and Analyzing Medical Device Trials Conducted in US and OUS Regioectation of the magnitude of regional differences and the statutory requirements in the USA. Examples are presented to illustrate the design and analysis based on our proposed procedure. Using the proposed two-tier procedure with an upfront explicit decision tree can increase the predictability and transparency of the regulatory decision making.
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Treatment Effect Estimation in Adaptive Clinical Trials: A Reviewas this research area has not been widely explored. In this chapter, we would like to discuss the impact of adaptation on the treatment effect estimation and compare some adjustment techniques in the adaptive trials based on simulation results.
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