Titlebook: Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics; A Replacement for We Michael Kinter,Car

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F. Su,W. Hwang,A. Mukherjee,K. Chakrabartystrong history of use for many classes of small molecules. As a result, the application of selected reaction monitoring to targeted quantitative proteomics can be seen as a straight-forward experiment based on sound principles, excellent equipment, and a distinguished history.

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Introduction to Quantitative Proteomics,ing quantitative proteomics, are based on an extensive foundation of fundamental and applied investigations. This history also applies to selected reaction monitoring. The ability of tandem mass spectrometry to enhance the specificity of an analysis was apparent in the 1970s and the technique has a

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Specificity of Detection Is the Key Attribute of Selected Reaction Monitoring,ges of the mass spectrometer are synchronized so that a signal is seen only when a molecular ion with a specific ./. is formed . that molecular ion fragments to a product ion with a specific ./.. The specificity of the analysis is increased by the unique amino acid sequence that defines a protein’s

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Sample Processing, largely purified peptides injected into the LC-tandem mass spectrometry system. As seen with essentially any advanced analytical technique, the overall success of the selected reaction monitoring experiment is dependent on the quality of these samples. The accuracy and precision of the assay requir

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