| 期刊全称 | Application of Monoclonal Antibodies in Tumor Pathology | | 影响因子2023 | Dirk J. Ruiter,Gert Jan Fleuren,Sven O. Warnaar | | 视频video | | | 学科分类 | Developments in Oncology | | 图书封面 |  | | 影响因子 | The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio imaging and appropriate targets for immunotherapy. In spite of undetec table differences with conventional histopathological approaches hetero geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology | | Pindex | Book 1987 |
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发表于 2025-3-21 18:17:58
