Titlebook: Antiplatelet Agents; Paolo Gresele,Gustav V. R Born,Clive P. Page Book 2012 Springer-Verlag Berlin Heidelberg 2012 Antithrombotic Therapy.

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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/a/image/158648.jpg

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Electromagnetic Response of Material Medialatelet activation intended to place the signaling pathways into context, the first section considers the early events of platelet activation leading up to integrin activation and platelet aggregation. The focus is on the G protein-mediated events utilized by agonists such as thrombin and ADP, and t

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https://doi.org/10.1007/978-1-4613-9064-0ical and pathophysiological conditions. Beyond hemostasis, platelets participate in wound healing, inflammation, infectious diseases, maintenance of the endothelial barrier function, angiogenesis, and tumor metastasis. Over the last 50 years enormous progress has been made in our understanding of th

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https://doi.org/10.1007/978-3-031-01702-5in the synthesis of platelet agonists, or membrane receptors mediating activation signals. Pharmacological interference with critical molecular pathways of platelet activation and aggregation may reduce the risk of atherothrombotic complications through mechanisms that are also responsible for an in

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Radiative Transfer in Particle Clouds,. Circulating platelets are maintained in a resting state and are activated at sites of vascular injury by exquisitely controlled mechanisms, thereby maintaining vascular integrity without causing intravascular thrombosis. As it became clear that platelets play a central role in arterial thrombosis,

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https://doi.org/10.1007/978-3-319-45355-2on have proven benefits in the prevention and resolution of atherothrombotic events. With regard to intracellular inhibition, phosphodiesterases (PDEs) are fundamental for platelet function. Platelets possess several PDEs (PDE2, PDE3 and PDE5) that catalyze the hydrolysis of cyclic adenosine 3′-5′-m

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