Titlebook: Antiplatelet Agents; Paolo Gresele,Gustav V. R Born,Clive P. Page Book 2012 Springer-Verlag Berlin Heidelberg 2012 Antithrombotic Therapy.

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https://doi.org/10.1007/978-1-4613-9064-0her, platelets play a critical role in both acute and chronic processes of the vascular wall, which makes them an attractive target for pharmacological strategies to treat arterial thrombosis and, potentially, also atheroprogression.

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https://doi.org/10.1007/978-3-319-45355-2a novel class of antiplatelet agents able to inhibit thrombin-mediated platelet activation has been developed, PAR-1 inhibitors. In this chapter, we will discuss the rationale underlying the development of this novel class of agents focus on the two drugs in the most advanced stages of development:

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G. Andersson,B. Hedin,G. Rudstamly by TXA., but also by prostaglandin (PG) D., PGE., PGF., PGH., PG endoperoxides (i.e., 20-HETE), and isoprostanes, all representing aspirin-insensitive mechanisms of TP activation. Moreover, TP are also expressed on several cell types such as macrophages or monocytes, and vascular endothelial cell

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https://doi.org/10.1007/978-0-387-46096-3ainst VWF-A3; ALX-0081 and ALX-0681, bivalent humanized nanobodies targeting the VWF-A1 domain; ARC1779 and its advanced formulation ARC15105, second-generation aptamers that bind the VWF-A1 domain; h6B4-Fab, a murine monoclonal antibody, and GPG-290, a recombinant chimeric protein, both directed ag

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Book 2012ield have been recorded. This is the first comprehensive handbook entirely dedicated to all the aspects of antiplatelet therapy. The book is divided into three main sections, pathophysiology, pharmacology and therapy, for a total of 23 chapters. A large group of leading experts from different Europe