Titlebook: Antioxidants and Cardiovascular Disease; Jean-Claude Tardif,Martial G. Bourassa Book 2000 Springer Science+Business Media Dordrecht 2000 L

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Lipoproteins and Oxidation: Clinical Aspects of Lipoprotein Metabolism and Oxidation,the detection and treatment of elevated LDLC has resulted in some reduction in cardiovascular events, but despite successful reductions in LDLC, atherosclerosis continues to progress in many patients [2]. An approximate 25% reduction in clinical cardiovascular events has been reported from many tria

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Pathogenesis of Atherosclerosis,e half million deaths annually, and countless other complications, in North America alone. Coronary plaques appear early in ones life, by the end of the second decade asymptomatic atherosclerotic lesions are present in most people. As these lesions grow they may eventually limit blood flow to the my

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The Antioxidant Hypothesis, oxidative-modification hypothesis of atherosclerosis. Several risk factors for atherothrombotic disease, such as hypercholesterolemia, hypertension, diabetes mellitus, cigarette smoking, and hyperhomocyst(e)inemia, promote oxidative reactions in the vasculature. Oxidant stress damages LDL, attracts

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Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease,xtracellular message across plasma membranes into the intracellular environment is called signal transduction or cell signaling. Recently, reduction-oxidation (redox) reactions that generate reactive oxygen species (ROS) have gained attention as important chemical processes that regulate signal tran