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Titlebook: Antifungal Drug Resistance; Methods and Protocol Damian J. Krysan,W. Scott Moye-Rowley Book 2023 The Editor(s) (if applicable) and The Auth

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期刊全称Antifungal Drug Resistance
期刊简称Methods and Protocol
影响因子2023Damian J. Krysan,W. Scott Moye-Rowley
视频video
发行地址Includes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts
学科分类Methods in Molecular Biology
图书封面Titlebook: Antifungal Drug Resistance; Methods and Protocol Damian J. Krysan,W. Scott Moye-Rowley Book 2023 The Editor(s) (if applicable) and The Auth
影响因子This detailed volume aims to elucidate the molecular mechanisms that underlie antifungal resistance. The book highlights methods to identify and characterize antifungal activity, to define and characterize strains with altered responses to antifungal drugs, to investigate the genetic and molecular mechanisms of these alterations of antifungal drug susceptibility, and, finally, to approach the study of these processes in animal models of fungal infection. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. .Authoritative and practical, .Antifungal Drug Resistance: Methods and Protocols. serves as an ideal resource for the field and a guide for investigators to study this important translational aspect of fungal biology..
Pindex Book 2023
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A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against ections, and yet treatment options are limited due to resistance to clinical antifungals and lack of broad-spectrum activity against molds. Technical challenges associated with molds have limited large-throughput screening efforts for anti-mold compounds: therefore, we adapted an assay for use with
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Drug Target Elucidation Through Isolation and Analysis of Drug-Resistant Mutants in product screening, and drug repurposing efforts, can identify compounds with favorable in vitro antifungal activity. However, these approaches will often identify compounds with no known mechanism of action. Herein, we describe a method utilizing the human fungal pathogen . to identify antifungal d
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Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathorrently, antifungal drug classes available to treat fungal infections remain limited and the emergence of drug-resistant strains threatens antifungal efficacy, necessitating the discovery and development of additional therapeutics. The construction of the . double-barcoded heterozygous deletion coll
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