Titlebook: Antiepileptic Drugs and Pregnancy; A Guide for Prescrib MJ Eadie,FJE Vajda Book 2016 Springer International Publishing Switzerland 2016 Ant

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Antiepileptic Drugs and Becoming Pregnant,ularly the older agents that induce formation of enzymes that catalyse the metabolism of steroidal sex hormones, also tends to decrease the circulating concentrations of steroidal hormones used for contraceptive purposes. This effect may increase the chances of undesired pregnancies occurring.

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Commonly Used Newer Antiepileptic Drugsout prior metabolism) being less increased. Relatively little information is available concerning the dispositions of the three drugs in the neonate, though there are published data for maternal plasma to breast milk concentration ratios.

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Particular Antiepileptic Drugs and Foetal Malformationssibility that the remaining currently used drugs are teratogens cannot be excluded, but there appears to be enough evidence to indicate that any teratogenic hazard arising from exposure to them is quite small.

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Antiepileptic Drugs, Cognition and Neurodevelopment evidence has become available that intrauterine valproate exposure may be associated with the development of autism-spectrum disorder in childhood. Not enough data exists to clarify the situation in this regard for the other antiepileptic drugs.

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Book 2016ther and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications. It also deals with the possible harmful effects of antiepileptic drug exposure during pregnancy on the phys

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Eismitte in the Scientific Imaginationders, recognising that the principles that apply in this situation are likely to also be valid in guiding the management of other disorders, particularly psychiatric ones, in which this class of drugs may also need to be used during human pregnancy

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