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Titlebook: Antiepileptic Drugs and Pregnancy; A Guide for Prescrib MJ Eadie,FJE Vajda Book 2016 Springer International Publishing Switzerland 2016 Ant

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发表于 2025-3-21 19:34:16 | 显示全部楼层 |阅读模式
期刊全称Antiepileptic Drugs and Pregnancy
期刊简称A Guide for Prescrib
影响因子2023MJ Eadie,FJE Vajda
视频video
发行地址Provides a rational basis for treatment decisions involving antiepileptic drug use during pregnancy and in those wishing to become pregnant.Offers an up-to-date, systematic account of the teratogenic
图书封面Titlebook: Antiepileptic Drugs and Pregnancy; A Guide for Prescrib MJ Eadie,FJE Vajda Book 2016 Springer International Publishing Switzerland 2016 Ant
影响因子A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications. It also deals with the possible harmful effects of antiepileptic drug exposure during pregnancy on the physical and intellectual development of the fetus. Clinicians have to balance the potential adverse effects of the medicine for the fetus and mother-to-be against the risks that uncontrolled seizures hold for both when treating pregnant women with antiepileptic drugs. Only recently have enough scientific data emerged to provide a rational basis for treatment decisions that take in both aspects. This work provides a single, accessible and up-to-date resource for busy clinicians.
Pindex Book 2016
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Antiepileptic Drug Disposition in Pregnancy and placenta at the time of childbirth, have consequences for the body’s handling of drugs. The physiological changes have little effect on the absorption of the orally administered drugs, but the expanded extracellular fluid volume of pregnancy and the increasing bulk of the uterus and its content
发表于 2025-3-22 08:33:45 | 显示全部楼层
The Older Antiepileptic Drugsn used in pregnancy, to provide a background to considering the alterations pregnancy and its aftermath produce in these parameters. The four drugs considered, viz. phenobarbitone, phenytoin, carbamazepine and valproate, are cleared from the body mainly by virtue of metabolism, and the clearance val
发表于 2025-3-22 09:49:39 | 显示全部楼层
Commonly Used Newer Antiepileptic Drugsn pregnant women, viz. lamotrigine, topiramate and levetiracetam. There is more information available for the first of these drugs than for the other two. The clearance value for lamotrigine, which is almost fully biotransformed to glucuronides, is considerably increased during pregnancy, with the c
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Antiepileptic Drugs and Foetal Malformations: A Possible Class Effectopment of foetal malformations. The occurrence of such malformations is relatively uncommon, and it has taken time and the accumulation of moderately sized data collections before the following information has emerged, viz.
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Antiepileptic Drugs, Cognition and Neurodevelopmentt trimester of human pregnancy may be associated with the occurrence of physical malformations in the foetus but, in addition, foetal valproate exposure poses a significant risk for the cognitive development of the infant, an effect that is dose dependent. Carbamazepine and lamotrigine exposures app
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