Titlebook: Antiepileptic Drug Discovery; Novel Approaches Alan Talevi,Luisa Rocha Book 2016 Springer Science+Business Media New York 2016 Antiepilepto

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The Use of Anti-inflammatory Drugs in Epilepsythe susceptibility to epileptic activity. Therefore, the search of pharmacological strategies focused on decreasing both neuroinflammation and neuronal excitability associated with epilepsy is important. This chapter is a review of several drugs that may be used for this purpose.

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Inflammatory Cytokines as Targets for Epilepsy Drug Therapyd after seizures in experimental models and, in some cases, still overexpressed later during the chronic stage. Increased levels of these cytokines have been found in the serum from epileptic patients. Pharmacological approaches in rodents support that neuroinflammation is involved in modulating sei

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Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepilexpressed ubiquitously throughout the brain in all nerve terminals independently of their neurotransmitter. It plays an important role in ensuring correct neurotransmission by priming vesicles for fusion. SV2A is the molecular target of the anticonvulsant drug levetiracetam (LEV), whose effects might

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Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?ids can regulate the expression of epileptic seizures as well as the epileptogenesis process. Some of them suggest that cannabinoids may represent a therapeutic approach for different types of epilepsy. However, experimental evidence indicates that the effects of cannabinoids depend on several exper

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Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapyted that glutamate plays an important role in seizure generation and spread. Glutamate is the predominant excitatory neurotransmitter in the brain, exerting its action through ionotropic and metabotropic receptors. Notably, a significant increase of extracellular glutamate release was observed in hi

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Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticitytability. Neurosteroids suppress seizures, and this action is particularly important in women with epilepsy, who may experience seizure exacerbation due to hormonal fluctuations associated with their menstrual cycle, called catamenial epilepsy. Neurosteroids exert their anticonvulsant action by incr

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Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Etivation of both receptor to EPO (EPO-R), which undergoes a classic dimeric conformation called (EPO-R)., and the EPOR-β common receptor (βCR). The interaction between EPO and EPO-R can prevent and repair tissue damage induced by hypoxia and neuroinflammation. The current chapter is focused on prese

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