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Titlebook: Antibody Therapy; Substitution – Immun Paul Imbach Book 2018 Springer International Publishing AG, part of Springer Nature 2018 Immunoglobu

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发表于 2025-3-21 19:02:59 | 显示全部楼层 |阅读模式
期刊全称Antibody Therapy
期刊简称Substitution – Immun
影响因子2023Paul Imbach
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发行地址Outlines indications for use of IgG concentrates and other modern immunomodulators.Reviews basic aspects of IgG concentrates.Provides an update on immunomodulatory IgG treatment in ITP.Examines mAbs a
图书封面Titlebook: Antibody Therapy; Substitution – Immun Paul Imbach Book 2018 Springer International Publishing AG, part of Springer Nature 2018 Immunoglobu
影响因子This practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.
Pindex Book 2018
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发表于 2025-3-22 00:11:24 | 显示全部楼层
From Immune Substitution to Immuno-modulationestones in the history of human immunoglobulins since the initial observation by Ogden C. Bruton who described replacement therapy in a single boy with agammaglobulinemia. Since then, the preparations used for treatment have been markedly improved with respect to tolerability, clinical efficacy, and
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Immunomodulatory Drugs and Monoclonal Antibodies development of most such disorders, but an external trigger may be required for the eventual development of the autoimmune disease. The development of pharmacologic agents to treat such disorders by inducing self-tolerance has progressed over the last 60 years. Historically termed immunosuppressive
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Essentials of the Production of Safe and Efficacious State-of-the-Art Polyclonal IgG Concentratesal use were threats for recipients (see Chap. . for additional information). “Standard IgG” preparations were the first available for clinical use. They were produced by the cold-ethanol fractionation methods and did not make an exception. Noninfectious severe AEs occurred while infectious AEs were
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