Titlebook: Antibody Glycosylation; Marija Pezer Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature

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Sweet Rules: Linking Glycosylation to Antibody Functionlasting immunity. Moreover, antibodies have become the most widely used platform for developing novel therapies against cancer and autoimmunity, requiring an in-depth understanding of how antibodies mediate their activity in vivo and which factors modulate pro- or anti-inflammatory antibody activiti

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Immunoglobulin G Glycosylation in Diseasesnant, and other diseases. This chapter contains an updated catalog of over 140 studies within which IgG glycosylation analysis was performed in a disease setting. Since the composition of IgG glycans is known to modulate its effector functions, it is suggested that a changed IgG glycosylation patter

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Immunoglobulin A Glycosylation and Its Role in Diseaseorms of IgA. The production of IgA rivals all other immunoglobulin isotypes. The large quantities of IgA reflect the fundamental roles it plays in immune defense, protecting vulnerable mucosal surfaces against invading pathogens. SIgA dominates mucosal surfaces, whereas IgA in circulation is predomi

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Die astronomischen Instrumente,rities require that the structure of a potential mAb drug product is comprehensively characterized employing state-of-the-art orthogonal analytical technologies; the PTM profile may define a set of critical quality attributes (CQAs) for the drug product that must be maintained, employing quality by

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Formen und Methoden des Sprachaufbaueshlighting possible difficulties and pitfalls. The application section describes the detailed characterization of .-glycosylation, utilizing multiplexed CGE with laser-induced fluorescence detection (xCGE-LIF). Besides a comprehensive overview on antibody glycosylation by comparing species-specific I