Titlebook: Antiangiogenic Agents in Cancer Therapy; Beverly A. Teicher Book 19991st edition Springer Science+Business Media New York 1999 angiogenesi

dilute

Intra- and Extracellular pH in Solid Tumorsabolites. Neoplastic cells metabolize glucose preferentially through glycolysis, even in an aerobic environment resulting in the production of lactic acid .. In solid tumors, the supply of oxygen is limited because of sluggish blood perfusion through a heterogeneously distributed vascular network, r

Abbreviate

Contribution of the Extracellular Matrix and Macrophages in Angiogenesissis is driven by a diverse array of soluble mediators, matrix molecules, and accessory cells that function to coordinate the growth, differentiation, and maturation of new capillaries in a strictly defined temporal and spatial pattern. In recent years, the role ofthe extracellular matrix (ECM) in an

Adenocarcinoma

Regulation of Angiogenesis by the Organ Microenvironmenthe biological heterogeneity of cancer cells in primary and secondary neoplasms. This heterogeneity is exhibited in a wide range of biologic characteristics, such as cell-surface receptors, enzymes, karyotypes, cell morphologies, growth properties, sensitivities to various therapeutic agents, and in

小鹿

小卷发

Role of Vascular Endothelial Growth Factor in Regulation of Angiogenesis healing and reproductive functions in the adult .. Angiogenesis is also implicated in the pathogenesis of a variety of disorders: proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis .,.

旧石器

Regulatory Aspects of Neovascularizationeception of angiogenic signals, chemotaxis, proteolysis of extracellular matrix, cell replication, cell-matrix adhesion, tube formation, and ligation of the newly formed vascular sprouts. The discovery of angiogenic cytokines and growth factors has greatly contributed to understanding ofthe regulati

hypnogram

许可

Thrombospondin as an Inhibitor of Angiogenesistors ., associated cells . and an overall balance of angiogenic factors in which inhibitors predominate over inducers .. Thrombospondin (TSP) is one of a small number of naturally occurring inhibitors of angiogenesis that is well-positioned to contribute to this maintenance of vascular quiescence in

连锁,连串

Matrix Metalloproteinase Inhibitors the earliest descriptions of MMPs was as depolymerizing enzymes, including that of small blood vessels,morefluid ..Sudequent research has shown that these enzymes paly a central role in the tissue remodeling associated with both physiological and pathogenic processes.

典型

Angiostatin Protein and Other Plasminogen Fragmentsinhibition of tumor growth by tumor mass had been hypothesized to be caused by concomitant immunity (a resistance to second tumor graft in the presence of the first growing tumor) in early publications .. Several other hypotheses have been proposed (reviewed in refs. . and .) but, similarly, had not