Titlebook: Anthracycline Chemistry and Biology II; Mode of Action, Clin Karsten Krohn Book 2008 Springer-Verlag Berlin Heidelberg 2008 biochemistry.bi

Dictation

https://doi.org/10.1007/978-3-476-99282-6ators have been developed. However, doxorubicin andclosely related anthracyclines still remain among the most effective antitumor agents. Multiple mechanismshave been proposed to explain their efficacy. They include inhibition of DNA-dependent functions, freeradical formation, and membrane interacti

制定法律

hankering

出没

障碍物

Einführung in die Analyse von Prosatexten tumor site while releasing the cytotoxic drug..Among immuno-conjugates representing a widely studied class of doxorubicin derivatives,the clinical development of cBR96-Dox, undoubtedly the most quintessential derivative, was discontinueddue to severe secondary effects. More potent cBR-96 analogues

lethal

https://doi.org/10.1007/978-3-476-98966-6raquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stress and drug metabolites. An intermediate in reductive glycosidiccleavage is a quinone methide, once proposed as an alkylating agent of DNA. Subsequent research nowimplicates formaldehyde as a mediator

掺假

https://doi.org/10.1007/978-3-476-98966-6-aminated sugar, namely 2-deoxy-.-rhamnose or 2-deoxy-.-fucose andthe second moiety is daunosamine, have been obtained upon synthesis of the appropriate activated sugarintermediate and glycosylation of the corresponding aglycones. The compounds containing 2-deoxy-.-fucose exhibit superior pharmacolo

Mammal

Fantasy

10楼

无王时期,

10楼