Titlebook: Anthracycline Chemistry and Biology II; Mode of Action, Clin Karsten Krohn Book 2008 Springer-Verlag Berlin Heidelberg 2008 biochemistry.bi

Employee

Doxorubicin Conjugates for Selective Delivery to Tumors, tumor site while releasing the cytotoxic drug..Among immuno-conjugates representing a widely studied class of doxorubicin derivatives,the clinical development of cBR96-Dox, undoubtedly the most quintessential derivative, was discontinueddue to severe secondary effects. More potent cBR-96 analogues

表状态

,Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs,raquinones, and as such are redox active. Their redoxchemistry leads to induction of oxidative stress and drug metabolites. An intermediate in reductive glycosidiccleavage is a quinone methide, once proposed as an alkylating agent of DNA. Subsequent research nowimplicates formaldehyde as a mediator

Grating

incarcerate

Nemorubicin,armitalia CarloErba Research Center in Italy. The idea was to develop doxorubicin analogues able to circumvent the emergenceof chemoresistance, in particular the multi-drug resistance. The drug was reported to be active in vitroagainst both murine and human tumor cells resistant to doxorubicin. Simi

Comprise

Anthracycline Chemistry and Biology II978-3-540-75813-6Series ISSN 0340-1022 Series E-ISSN 1436-5049

caldron

groggy

Karsten KrohnSeries presents critical reviews of the present position and future trends in modern chemical research.Short and concise reports on chemistry, each written by the world renowned experts. Still valid a

心胸狭窄

Simulate

Thyroxine

978-3-642-09495-8Springer-Verlag Berlin Heidelberg 2008