Titlebook: Annual Update in Intensive Care and Emergency Medicine 2021; Jean-Louis Vincent Book 2021 The Editor(s) (if applicable) and The Author(s),

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Complex Immune Dysregulation in COVID-19 and Implications for TreatmentARDS) seem to have considerable heterogeneity. Pathogenesis is driven by monocytes, levels of which are increased in the blood and which migrate from the circulation to the alveolar space to propagate pro-inflammatory phenomena. At the stage of severe illness, the nucleotide-binding domain-like rece

Affluence

Measuring Vitamin C in Critically Ill Patients: Clinical Importance and Practical Difficulties—Is Itrs, there has been increasing interest in the effects of intravenous vitamin C in critically ill patients, but results of multiple clinical trials are not consistent. A possible explanation is the heterogeneity in study designs and included patients. Patients with vitamin C deficiency may benefit mo

Heterodoxy

Controversies on Non-renal Extracorporeal Therapies in Critically Ill COVID-19 Patientspatients, including those who are affected by Coronavirus Disease 2019 (COVID-19) and severe acute kidney injury. Cytokine release syndrome can occur during COVID-19-associated multiorgan failure and can be treated with techniques such as hemoperfusion, therapeutic plasma exchange or hemodiafiltrati

insipid

Secondary Infections in Critically Ill Patients with COVID-19nfections during the intensive care unit (ICU) stay, mainly due to the prolonged length of stay, the impairment of the immune system and the use of drugs interfering with immune system function (i.e., corticosteroids, cytokine inhibitors). Data describing the epidemiology of secondary infections in

Entreaty

Heart Dysfunction in Septic Patients: From Physiology to Echocardiographic Patternspt recognition and treatment to provide adequate oxygen utilization to the cells. Initial characterization of sepsis-associated cardiovascular dysfunction was based on clinical patterns identified by physical examination; however, the use of invasive and, more recently, non-invasive tools for hemody

florid

Non-adrenergic Vasopressors in Septic Shock: Overview and Updateicient to achieve this goal. Current guidelines recommend norepinephrine as the first-choice vasopressor in this context; however, some conditions, such as refractory septic shock, may require high doses of norepinephrine, which may be associated with various adverse effects and increased mortality

COKE

Pathophysiology and Clinical Implications of the Veno-arterial PCO2 Gaph mortality rate. Under these circumstances, tissue perfusion and cellular oxygenation are commonly assessed by blood lactate and venous oxygen saturation (SvO.). Venous-to-arterial difference in CO. partial pressure (Pv-aCO. gap) is another parameter, which can easily be obtained (through simultane

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