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Titlebook: Animal Models of T Cell-Mediated Skin Diseases; T. Zollner,H. Renz,K. Asadullah Conference proceedings 2005 Springer-Verlag Berlin Heidelb

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期刊全称Animal Models of T Cell-Mediated Skin Diseases
影响因子2023T. Zollner,H. Renz,K. Asadullah
视频video
学科分类Ernst Schering Foundation Symposium Proceedings
图书封面Titlebook: Animal Models of T Cell-Mediated Skin Diseases;  T. Zollner,H. Renz,K. Asadullah Conference proceedings 2005 Springer-Verlag Berlin Heidelb
影响因子.Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery..
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T-Cell Receptor Transgenic Models of Inflammatory Disorders: Relevance for Atopic Dermatitis?,
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Making Gene-Modified Mice,ly play a central role in biomedical research in the years to come, hopefully leading to the better understanding of pathogenic mechanisms and to new, more effective therapeutic approaches to human disease.
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Murine Models of Atopic Dermatitis,ifferent approaches increase the size and versatility of the toolkit available, as shown by deletion of genes in NC/Nga mice, thus allowing even deeper insights in the mechanism of AD. Mice with a spontaneous AD phenotype are also suitable for drug testing and development. This also applies to the c
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