Titlebook: Animal Models of T Cell-Mediated Skin Diseases; T. Zollner,H. Renz,K. Asadullah Conference proceedings 2005 Springer-Verlag Berlin Heidelb

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T. Takemura,S. Watanabe,Y. Ukaits of the disease. Thus several transgenic and knockout mouse models were helpful to a certain degree in improving our understanding of AD pathophysiology. However, genetic manipulation of a single cytokine obviously cannot mirror the whole picture of a complex disease such as AD. Neither the intera

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Documents about Accounting Standards in the pathogenesis of atopic dermatitis in humans. EC sensitization with protein allergens induces dermatitis manifested by epidermal and dermal thickening and characterized by the dermal accumulation of CD4. T cells, eosinophils, and degranulated mast cells. In addition, allergen-sensitized skin

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https://doi.org/10.1007/b138968ing effects on the development of immune responses. The biological effect of IL-4 depends on the primary target cell of this cytokine during an immune reaction, and factors such as the time of cytokine application and concentration during various phases of immune responses ultimately determine wheth

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Outlook and Study Process of Questionnairesmal models for both acute and chronic ACD. Some of the more established models are already extensively characterized and have proven to be T cell-dependent with an involvement of Th1 and Tc1 cells. They display at least some of the classical histological hallmarks of human ACD, and responses to expe

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https://doi.org/10.1007/b138119Animal Models of Skin Diseases; Asthma; Atopic Dermatitits; Contact dermatitis; Gene-modified mice; Psori

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Making Gene-Modified Mice,unprecedented tool for the in vivo analysis of gene function in mammals. Studies in gene-modified mice have made a major contribution to our current understanding of the molecular mechanisms governing mammalian embryonic development and physiology. Furthermore, this technology has allowed the genera

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Modelling Gene-Environment Interactions in Th1- and Th2-Dominated Diseases of Laboratory Animals,gulation secondary to decreased exposure to certain microorganisms that have been present throughout our evolutionary history. It is argued that these organisms are effectively part of our physiology, and are recognised as harmless by the innate immune system, which then activates immunoregulatory c