Titlebook: Animal Cell Culture; Mohamed Al-Rubeai Book 2015 Springer International Publishing Switzerland 2015 Animal Cell Culture.Biologics.Biopharm

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Arthashastra of Kautilya and Managementsuccess was achieved in spite of the concern of the “shear sensitivity” of animal cells. In this contribution, a summary of the current state of this “shear sensitivity” concern will be discussed, demonstrating that it is not in general a problem with current bioprocess. Example of what is considere

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Motivation: Eastern and Western Conceptsmetabolism properties and to establish and ensure reproducible cell cultivations. Monitoring not only comprises biological parameters, like cell count and viability, but also physiological parameters, like substrate, metabolite and possibly product concentrations. Furthermore, a large set of physico

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Motivation: Eastern and Western Conceptsf variability in composition, cost but particularly the potential for contamination with viruses or prions has been the driver for the substitution of serum with a more defined and animal-component free media. For some cell lines substitution with just a few simple ingredients can provide an effecti

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https://doi.org/10.1007/978-81-322-0472-5l as other attributes critical to its use as a biotherapeutic. Therefore our understanding of the glycosylation pathway, factors that affect it, and our ability to manipulate glycosylation are essential in producing superior biotherapeutics. The complex synthetic pathway of N-linked glycosylation oc

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Ferdinand Konček,ll’ja Skoček,Lubomír Title been unstructured, unsegregated and empirical. However, with the advancement in analytical techniques such as Raman spectroscopy and flow cytometry for monitoring the state variables, structured, segregated and mechanistic models have been developed to provide more understanding of the underlying

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https://doi.org/10.1007/978-3-322-82834-7particularly suitable for the production of high-value products on small and medium scales, and in cases where fast and safe production is a requirement. Thus, it is not surprising that SU bioreactors have established themselves for screening studies, cell expansions, and product expressions where t

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Power Thinking: Denken Sie sich zum Erfolg,. However, the system has been relevant for many years, being used for the manufacturing of recombinant veterinary vaccines, as a workhorse in the research laboratory, as an important tool for new drug discovery and as an important source of commercial materials and reagents for research. In this ch