Titlebook: Anemia in the Young and Old; Diagnosis and Manage Robert T. Means Jr. Book 2019 Springer Nature Switzerland AG 2019 congenital marrow failu

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https://doi.org/10.1007/978-94-009-5400-7 second most common etiology of acquired anemia in adult patients, with only iron deficiency from blood loss being more frequent. In reviews of the etiologies of anemia in elderly patients, the single most frequent etiology is a syndrome referred to as “unexplained anemia of the elderly (UAE).” Both

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Ken Fox,Iwan P. Williams,J. Huntematopoiesis, presumably as a consequence of a competitive fitness advantage in the setting of an aging HSPC pool. Genetic analyses of large population cohorts have demonstrated consistently that clonal hematopoiesis is detectable in the blood of subjects without a clinically apparent myeloid neopla

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Clonal Hematopoiesis and Cytopenias in the Elderlyesis develop a myeloid malignancy; thus, the term “clonal hematopoiesis of indeterminate potential” (CHIP) has been suggested to describe the acquisition of somatic mutations associated with clonal expansion without evidence of hematologic disease. Mutations in the epigenetic modifiers ., ., and . a