Titlebook: Analysis of Free Radicals in Biological Systems; A. E. Favier,J. Cadet,J.-L. Pierre Book 1995 Springer Basel AG 1995 DNA.Lipid.Oxidation.P

上流社会

Nitric oxide: Chemistry and biologyical, organic radicals and transition metals. During these reactions, .NO can be converted to NO., the nitrosonium ion, NO., the nitroxyl anion or to ONOO., the peroxynitrite anion. Synthetic .NO donors are compounds which can decompose into .NO and may have applications as vasodilators or antiproliferative agents.

时间等

Oxidative damage to DNAinvolving the transient formation of radical cautions. In addition, the main available assays for monitoring the formation of oxidized bases within cellular DNA are presented (mostly chromatographic methods associated with various detection techniques).

Herbivorous

Oxidation of low density lipoprotein (LDL) by cells True, vitamin E may be safe at quite high doses without evidence of major toxicity [1], however, antioxidants such as ., . and probucol do have toxicity and side-effects associated with their intake. Also, very little else is known about their normal physiological functions or their potential interactions with other drugs.

吞噬

低能儿

HILAR

Measurement of one of the features of apoptosis: DNA fragmentatione stress. Dexamethasone can induce apoptosis and trigger a quantitative increase in lipid peroxidation. This work shows two means to measure with flow cytometry DNA fragmentation in mouse thymocytes after dexamethasone treatment. Alternatively. electrophoretic analysis of thymocyte lysate DNA is performed.

antecedence

AXIS

Lars Brehm,Jessica Slamka,Andreas Nickmannchemistry to evaluate . protein free radical attack. The measurement of sulfhydryl and carbonyl are an interesting way to evaluate the free radical attack of plasma protein. These measurements involve a spectrophotometric method using respectively for thiol and carbonyl groups 5,5’-dithio-bis(2-nitrobenzoic acid) and 2,4-dinitrophenylhydrazine.

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Affluence

Pro-oxidant and antioxidant effects of nitric oxiden nitric oxide may also react with peroxyl radicals, such as lipid peroxyl radicals, and inhibit free radical chain reactions such as lipid peroxidation..This chapter discusses experimental sources of nitric oxide and peroxyntirite and the potential pro-oxidant and antioxidant effects of nitric oxide in biological systems.