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Titlebook: An Antigen Depository of the Immune System: Follicular Dendritic Cells; Marie H. Kosco-Vilbois Book 1995 The Editor(s) (if applicable) and

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发表于 2025-3-21 19:36:13 | 显示全部楼层 |阅读模式
期刊全称An Antigen Depository of the Immune System: Follicular Dendritic Cells
影响因子2023Marie H. Kosco-Vilbois
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学科分类Current Topics in Microbiology and Immunology
图书封面Titlebook: An Antigen Depository of the Immune System: Follicular Dendritic Cells;  Marie H. Kosco-Vilbois Book 1995 The Editor(s) (if applicable) and
影响因子Follicular dendritic cells (FOe) are unique among cells of the immune system. While their morphological characteristics re­ sulted in their inclusion as a ‘dendritic cell type‘, tt1ey differ quite significantly from the other members of the dendritic cell family. In contrast to T-cell-associated dendritic cells or the Langerhans cells found in the skin, FOe reside in highly organized B cell follicles within secondary lymphoid tissues. This site of resi­ dence provided a nomenclature committee in 1982 with the second descriptive factor for the derivation of their name. The cardinal feature of FOe is to trap and retain antigen on the surface of their dendritic processes for extended amounts of time and it is this feature that provides the conceptual compo­ nent for the title of this book. In response to an antigenic challenge, primary B cell follicles undergo dynamic events, giving rise to germinal centers which are associated with activation, expansion, and differentiation processes of B cells. The interactions of B cells with Foe and T cells in the germinal centers are essential for generating the complete repertoire of antibody isotypes obtained during an antibody response. In add
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https://doi.org/10.1007/978-3-662-26166-8ing the accessory activities of most accessory cells, such as DC and macrophages, have been collected using in vitro experimentation. In contrast, most of the data available on FDC has been collected using in vivo models. We have reviewed these in vivo data on murine FDC in a number of recent articles.
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https://doi.org/10.1007/978-3-662-26166-8be directly involved in all these events. Based on the histological observations depicted in Fig. 1, follicular B cell response can be divided into three distinct stages, in which different B cell events occur:
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https://doi.org/10.1007/978-3-642-66144-0 similar to stages described by B. and U. (1990) , B. etal. (1985), B. etal. (1985) , G. etal. (1986) , J. etal. (1985), Ö. etal. (1989) , P. et al. (1989), R. et al. (1986,1990) , and W. (1990) (Fig. 1):
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https://doi.org/10.1007/978-3-642-66144-0 predominant including the nodular paragranuloma, nodular sclerosis, mixed cellularity, and lymphocyte depleted (L. and B. 1966). An estimated 4 new patients with Hodgkin’s disease per 100 000 population will be detected yearly. By chemotherapy and/or radiation approximately 75% of patients with Hodgkin’s disease can be cured.
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Follicular Dendritic Cells: Antigen Retention, B Cell Activation, and Cytokine Production,, memory) circulating B cells and preplasma cells that will finish their differentiation process elsewhere. The humoral response also matures during the germinal center reaction through the mechanisms of class switching, somatic mutation, and clonal selection (reviewed in K. and G. 1992 ; M. 1994).
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