Titlebook: Alzheimer’s and Parkinson’s Diseases; Recent Developments Israel Hanin,Mitsuo Yoshida,Abraham Fisher Book 1995 Springer Science+Business Me

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宽度

myopia

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Rotierende Luft- und Kondensatpumpened by Brown and Marsden, 1988; Sagar and Sullivan, 1988). The cognitive deficits occur particularly on “executive” tasks, which are known to be sensitive to frontal lobe dysfunction raising the possibility that a frontal lobe disorder is the basis of the majority of the cognitive impairment in the d

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GREEN

https://doi.org/10.1007/978-3-322-98722-8Recent advances in molecular biology have identified the molecular pathology of the disease, consisting of accumulation of “prion protein”. Epidemiologic studies demonstrate that CJD is in most cases a sporadic disease. Cases with a familial background have been shown to result, in many cases, from

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旧石器时代

https://doi.org/10.1007/978-3-662-02209-2er amounts in brains of neuropsychologically normal, aged human subjects. AD-type brain amyloid consists of aggregated A. peptides which are 39–43 amino acid residues in length. A. is derived, by proteolytic processing, from a larger amyloid .-protein precursor (APP), which is a transmembrane glycop

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https://doi.org/10.1007/978-3-662-30329-0ce cleavage occurs in the endosomal-lysosomal compartment to generate the entire .A4 peptide sequence; the second which is “non-amyloidogenic” and involves the secretory cleavage of APP at a site within the (3A4 sequence (for a review see Selkoe, D.J., 1993). Since APP metabolism may become disrupte