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Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv

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发表于 2025-3-21 19:57:28 | 显示全部楼层 |阅读模式
期刊全称Alzheimer’s Disease Research
期刊简称What Has Guided Rese
影响因子2023Christian Behl
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发行地址Aims to answer why—after more than 100 years of Alzheimer‘s research—there is still no convincing therapy available.Informs on leading perspectives and key developments of Alzheimer‘s research from it
图书封面Titlebook: Alzheimer’s Disease Research; What Has Guided Rese Christian Behl Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusiv
影响因子.This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer‘s Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer‘s Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer‘s pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explainthe pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed?.In this book, Behl tries to answer these questions. Starting with the historical backgroun
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发表于 2025-3-21 21:47:58 | 显示全部楼层
发表于 2025-3-22 00:59:18 | 显示全部楼层
,Alzheimer’s Disease Research After 1945: The Recommencement,ative disorders. In addition to Alzheimer’s, several other types of dementia exist. Alzheimer’s disease research officially set off with the introduction of the label “Alzheimer’s disease” in 1910, but similar neurodegenerative processes had already been described years before..The restart of Alzhei
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发表于 2025-3-22 16:18:28 | 显示全部楼层
,The , of Alzheimer’s Disease,itatory neurotransmitter in the vertebrate nervous system. This neurotransmitter displays its activities via different types of receptors localized at the nerve cell membrane. Physiologically, glutamate and its receptors (especially the so-called NMDA type) are involved in higher brain functions suc
发表于 2025-3-22 19:07:15 | 显示全部楼层
,Biochemistry and Genetics Point Out a Prime Suspect for Causing Alzheimer’s Disease,rsh chemical conditions, the sequence of 24 amino acids of the amyloid beta peptide isolated from cerebrovascular material was unraveled at the UCSD by Georg Glenner and Caine Wong in 1984. Shortly thereafter, the German and Australian researchers Konrad Beyreuther and Colin Masters, respectively, p
发表于 2025-3-22 22:50:31 | 显示全部楼层
Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor, peptide. A fierce competition commenced between several research groups during the year 1987 around the further molecular characterization of this peptide..Key findings were the cloning of its precursor protein (APP), the molecular assignment of the APP gene to chromosome 21, and the discovery that
发表于 2025-3-23 04:36:06 | 显示全部楼层
,Step by Step Toward an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease,of molecular and cellular findings around this peptide was delivered and, consequently, in 1992 the . was presented. This hypothesis assigned the amyloid beta protein the role as initial trigger standing at the beginning of a cascade of pathogenic events. In the 15 years from 1984 to 1999, the puzzl
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