Titlebook: Alzheimer‘s Disease; Methods and Protocol Nigel M. Hooper Book 2000 Humana Press 2000

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https://doi.org/10.1007/978-3-322-98663-4fect. This is a simplistic view, as it has been shown that for certain forms of apoptosis an increase in hyperpolarizing K.currents may be involved (.). It is, therefore, important to consider the functional effects of any changes in membrane conductances or ion channel currents induced by Aβ in the light of neurotoxic effects of the peptide.

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Walter Baumeister,Helmut Burghardtc domain, except that unlike APP, APP-like proteins lack the β-amyloid sequence. It has been thought that APP and APLP2 have a similar physiological function (.). In contrast, APLP1 is believed to differ functionally from APP and APLP2, although the physiological functions of these APP family proteins have not yet been well analyzed.

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,Effects of the β-Amyloid Peptide on Membrane Ion Permeability,fect. This is a simplistic view, as it has been shown that for certain forms of apoptosis an increase in hyperpolarizing K.currents may be involved (.). It is, therefore, important to consider the functional effects of any changes in membrane conductances or ion channel currents induced by Aβ in the light of neurotoxic effects of the peptide.

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Book 2000e played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.

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https://doi.org/10.1007/978-3-322-98856-0the deposition of multimeric Aβ fibrils into plaques is a necessary step in AD onset, there is still uncertainty as to how Aβ and neuritic plaques might cause the neuropathology that leads to the dementia that is characteristic of this disease.

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https://doi.org/10.1007/978-3-662-26346-4ss visible but equally important advance has been a quantum leap in expertise in clinical trial methodology. This chapter reviews the methodological underpinnings of clinical trials in AD: patient selection issues, key design issues, and an overview of currently available agents and the prospects for drugs of the future.

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