Titlebook: Alzheimer‘s Disease; Methods and Protocol Nigel M. Hooper Book 2000 Humana Press 2000

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书目名称Alzheimer‘s Disease影响因子(影响力)




书目名称Alzheimer‘s Disease影响因子(影响力)学科排名




书目名称Alzheimer‘s Disease网络公开度




书目名称Alzheimer‘s Disease网络公开度学科排名




书目名称Alzheimer‘s Disease被引频次




书目名称Alzheimer‘s Disease被引频次学科排名




书目名称Alzheimer‘s Disease年度引用




书目名称Alzheimer‘s Disease年度引用学科排名




书目名称Alzheimer‘s Disease读者反馈




书目名称Alzheimer‘s Disease读者反馈学科排名

流眼泪

,The Genetics of Alzheimer’s Disease,r’s disease as occurring in the presenium. The same neuropathological changes occurring in brains over the age of 65 were called “senile dementia.” Because there have been no clinical or pathological features to separate the two groups, this somewhat arbitrary distinction has been abandoned. Althoug

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dictator

,Quantifying Aβ1–40 and Aβ1–42 Using Sandwich-ELISA,ecursor protein (APP) that alter Aβ production are linked to a subset of familial AD (FAD) cases with autosomal penetrance (reviewed in .. .). Several of these FAD-associated APP mutations, as well as FAD-associated mutations in the presenilin 1 (PS1) and presenilin 2 (PS2) genes, lead to an increas

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growth-factor

incredulity

,Effects of the β-Amyloid Peptide on Membrane Ion Permeability, electrophysiological techniques that can be employed to isolate and record specific membrane conductances that may be altered by Aβ. In general, an increase in conductances that cause depolarization of the cell membrane may be considered excitotoxic since they will: (.) increase Ca.influx through v

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拘留

Posttranslational Modifications of Amyloid Precursor Protein,ail (.). Translation of APP occurs at the endoplasmic reticulum (ER) and the protein is translocated into the ER lumen. The N-terminal domain of APP is directed towards the luminal compartment of the ER, whereas the C-terminal domain faces the cytoplasm. After synthesis, APP passes from the ER to th