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Titlebook: Alternatives to Animal Testing; Proceedings of Asian Hajime Kojima,Troy Seidle,Horst Spielmann Conference proceedings‘‘‘‘‘‘‘‘ 2019 The Edit

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Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermisuitable growth medium. To find out that RHE has been successfully reconstructed, measured percentage of cell life, made histology preparation to see the existence of cell nucleus, and conducted Immunohistochemical examination to see existence of integration (bond) between antigen. From the research
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Approaches to Reducing Animal Use for Acute Toxicity Testing: Retrospective Analyses of Pesticide Dfor formulations and 41% for AIs using the GHS. Underprediction of dermal hazard was 1% for formulations and 3% for AIs using the EPA system and 1% for formulations and 3% for AIs using the GHS. While concordance overall was modest, the very low underprediction rates show that acute oral hazard cate
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Alternatives and Refinement for Animal Experimentation in Cancer Research,f cancer. This paper highlights the available alternatives and refinements for animal experimentation. A positive note is that if coupled with the refinements, even a minimised number of animal usage shall also yield the meaningful and acceptable results.
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3Rs in Quality Control of Human Vaccines: Opportunities and Barriers,lementation of 3Rs for some vaccines when distributed worldwide. This reinforces the need for enhancing international harmonization and cooperation efforts..In this chapter, we review the use of laboratory animals in human vaccines research and quality control and describe the vaccine manufacturing
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Mechanism-Based Evaluation System for Hepato- and Nephrotoxicity or Carcinogenicity Using Omics Tecso developed a new prediction system named “CARCINOscreen.” for evaluating the carcinogenic potentials of chemicals using the gene expression profiles of liver and kidney tissues from rats after a 28-day repeated administration. The prediction system could predict the carcinogenicity potential of a
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Alternative Methods for Developmental Toxicity Testing Using Mouse ESCs,mpound’s toxicity level and for establishing a prediction model that utilizes those endpoints. The EB area-based toxicity test (EBT) is an animal-free, novel drug screening system that can be useful in evaluating of various embryotoxic chemicals within a short time.
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