Titlebook: Alternatives for Dermal Toxicity Testing; Chantra Eskes,Erwin van Vliet,Howard I. Maibach Book 2017 Springer International Publishing AG 2

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The epiCS® Skin Corrosion Test Methodrding to OECD TG 431. Recently, the EU Classification, Labelling and Packaging Regulation (EU CLP) system required the subcategorization of corrosive chemicals into the UN GHS optional subcategories 1A and 1B and 1C. Eighty chemicals including solids, semi-solids and liquids of different chemical cl

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Overview on Current Status and Combination of Test Methodsspite these advances, more efforts are still needed to refine the existing methods and to further develop new methods that lead to an improved awareness of the real mechanisms of a chemical in triggering a sensitization reaction in exposed human beings. An important observation is that detailed anal

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Utilization of Peptide Reactivity Assays for the Prediction of Skin Sensitizationns with proteins has long been established as a key step in induction of skin sensitization. Based on this, two . approaches have been developed: the Direct Peptide Reactivity Assay (DPRA) and the Peroxidase Peptide Reactivity Assay (PPRA). Both assays utilize synthetic peptides which contain either

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https://doi.org/10.1007/978-3-8349-9707-4tained during the validation study. Part of this chapter also describes other EpiDerm™ skin irritation protocols that can be used for the safety assessment of final cosmetic products and for testing extracts from Medical Devices in line with the ISO 10993.