Titlebook: Allostery; Methods and Protocol Luisa Di Paola,Alessandro Giuliani Book 2021 Springer Science+Business Media, LLC, part of Springer Nature

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柳树；枯黄

https://doi.org/10.1007/b101090a perturbation event. Allostery, which has been coined the “second secret of life,” is a fundamental property of most dynamics proteins. Most of critical questions surrounding allostery are largely unresolved. One of the key puzzles is to describe the physical mechanism of distant coupled conformati

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Jingoism

International Series in Outreach Scholarshipt about by minor perturbations by natural processes like binding of a ligand or protein-protein interaction. The challenge lies in capturing minute changes at the residue interaction level and following their propagation at local as well as global distances. While macromolecular effects of the pheno

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Culture and Emotional Development,ssical molecular dynamics (MD) simulations, protein motions can be analysed by means of mutual information between pairs of amino acid residues, providing dynamical weighted networks that contains fundamental information of the communication among amino acids. The CNA method has been successfully ap

不幸的人

Pituitary-Gland

https://doi.org/10.1057/9780230624931 constant domains, which do not directly interact with antigens. Such effects are difficult to study experimentally; however, molecular dynamics simulations and subsequent residue interaction network analysis provide insight into the allosteric communication between the antigen-binding CDR region an