Titlebook: Allostery; Methods and Protocol Luisa Di Paola,Alessandro Giuliani Book 2021 Springer Science+Business Media, LLC, part of Springer Nature

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Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular S the cells alive or to kill them through mechanisms such as apoptosis. To complicate this picture, cancer cells that express mutant p53 becomes addicted to the mutant activity, so that the mutant variant features a myriad of gain-of-function activities, opening different venues for therapy. This mak

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Cooperativity and Allostery in RNA Systems,emical cues. Although initially used to describe the impact of small molecules on the conformation and activity of protein enzymes, the definition of this term has been significantly broadened to describe long-range conformational change of macromolecules in response to small or large effectors. Suc

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https://doi.org/10.1007/978-94-009-4281-3s’ showing a sensible adaptation to their environment by the production of appropriate behavior when facing a specific stimulus. This fact qualifies (from the ‘effector’ side) proteins as nanomachines working as catalysts, motors, or switches. However (from the sensor side), the need to single out t

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