Titlebook: Alcoholism: A Molecular Perspective; T. Norman Palmer Book 1991 Plenum Press, New York 1991 Calcium.Pathogene.calcium channels.enzymes.met

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Ethanol-Induced Phosphorylation of Cytokeratins in Primary Cultured Hepatocytes, and stability of intermediate filaments including intermediate filaments composed of cytokeratins (CKs). Initiation of the phosphorylation is through signal transduction by agonist receptor G protein activation of a catalyst such as cyclic AMP or phospholipase C which activate PKA or PKC, respectiv

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Cloning and Characterization of New Alcohol Dehydrogenase and Aldehyde Dehydrogenase Isozymes,dize varieties of alcohols and aldehydes, and play a role, not only in alcohol detoxification, but also in the metabolism of drugs, neurotransmitters and other endogenous biologically active alcohols and aldehydes.

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Physiological Role of Aldehyde Dehydrogenase (EC 1.2.1.3),te specificity. Both specific and non-specific enzymes are active with acetaldehyde as substrate (Pietruszko, 1989). Aldehyde dehydrogenase (EC 1.2.1.3) from human liver and brain as well as some specific enzymes including glutamic-γ-semialdehyde dehydrogenase (EC 1.5.1.12) from human liver (Forte-M

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The Alcohol Dehydrogenase System in the Rat: Comparison with the Human Enzyme,.1.1) started early (Markovic et al., 1971; Arslanian et al., 1971) and continued more recently (Crabb et al., 1983; Lad and Leffert, 1983, Mezey and Potter, 1983). These reports focused on the liver form that is most active with ethanol. During the last decade a great amount of information has been

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Genetic Polymorphisms of Alcohol Metabolizing Enzymes and Their Significance for Alcohol-Related Prism of neurotransmitters, fatty acids and glutathione, and in clearance of biogenic toxic substances. Genetic abnormalities, and consequent alteration of activity and kinetic properties of any one of the ADH and ALDH isozymes would potentially affect one’s sensitivity to alcohol and vulnerability in

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Biochemical and Genetic Studies in ALDH1-Deficient Subjects,cal properties (Yoshida .., 1990). Liver mitochondrial aldehyde dehydrogenase (ALDH.) probably plays a major role in acetaldehyde metabolism as its low k. (1–2μM) is compatible with the circulating acetaldehyde levels after alcohol ingestion in both normal subjects and alcohol abusers (Arthur et al.

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Genetic Linkage Analysis: Simple Solutions for Complex Traits?,ajor goal with important implications. Such identification could greatly increase our understanding of diseases whose pathophysiology and clinical course are currently unknown. In turn, this could lead to logical improvements in the way the disorder is treated. Furthermore, antenatal diagnosis and t