Titlebook: Advantages and Problems with Non-Opioids in Pain Management; Vancouver, Canada, A Michael J. Parnham Conference proceedings 1997 Birkhäuser

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Dipyrone in pain management,c efficacy of dipyrone is broad and comparable to that of the non-steroidal anti-inflammatory drugs (NSAIDs) and tramadol. Because dipyrone is a weak cyclo-oxygenase inhibitor, its use is not associated with gastric irritation, an important advantage for long-term administration. Uniquely, dipyrone

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Comparative safety of non-opioids,rofile and incidence of other AEs are not taken into account. An approach to the evaluation of the public health impact of AEs with non-opioid analgesics has now been taken in which the total risk of short-term use of these drugs in the community was estimated. The three dimensional approach involve

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Concluding remarks,several clinicians from Europe, Latin-America and Asia with long experience with dipyrone use in clinical practice emphasized its value, particularly in children, who have increased susceptibility to several adverse effects of NSAIDs. Recent clinical and epidemiological studies confirm the experienc

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