Titlebook: Advances in Systems Biology; Igor I. Goryanin,Andrew B. Goryachev Conference proceedings 2012 The Editor(s) (if applicable) and The Author

渐强

Climate

Evolution of the Cognitive Proteome: From Static to Dynamic Network Modelslities of the brain. Highly dynamic, cell type specific and intricately regulated, the synaptic proteome presents many challenges to systems biology approaches, yet this is likely to be the best route to unlock a new generation of neuroscience research and CNS drug development that society so urgent

micronized

Molecular Systems Biology of Sic1 in Yeast Cell Cycle Regulation Through Multiscale Modelingion. Failure of this control plays a role in cancer and molecules called cyclin-dependent kinase (Cdk) inhibitors (Ckis) exploit a critical function in cell cycle timing. Here we present a multiscale modeling where experimental and computational studies have been employed to investigate structure, f

平淡而无味

Proteome-Wide Screens in , Using the Yeast GFP Collectionfocus of many pioneering efforts, including the systematic construction and analysis of gene deletion mutants. Over the past decade, many large-scale studies have made use of the deletion and other mutant collections to assay genetic interactions, chemical sensitivities, and other phenotypes, contri

变化无常

Unraveling the Complex Regulatory Relationships Between Metabolism and Signal Transduction in Cancers, even under aerobic conditions. The Warburg effect appears to be an intrinsic component of most cancers and there is evidence linking cancer progression to mutations, translocations, and alternative splicing of genes that directly code for or have downstream effects on key metabolic enzymes. Many

注意

The Cell as a Thermostat: How Much does it Know?nsing element, an output switch, and an external control. But they differ in their origins. A thermostat is designed and made by humans and embodies their understanding of seasonal fluctuations in temperature and how these affect room comfort. By contrast, the bacterial system is self-contained and

noxious

Stem Cell Differentiation as a Renewal-Reward Process: Predictions and Validation in the Colonic Crys maintained. This process is inherently stochastic due to the small number and stochastic division patterns within the stem cell compartments, as well as the essentially stochastic differentiation events that follow the initial stem cell expansion. Here we propose a new formalism to describe this p

Atrium

浮雕宝石

insipid

An Ensemble Approach for Inferring Semi-quantitative Regulatory Dynamics for the Differentiation of nterest but also since it is expected to play an increasingly important role in regenerative medicine, in particular with the advert to induced pluripotent stem cells. These ESCs give rise to the formation of the three germ layers and therefore to the formation of all tissues and organs. Here, we pr