Titlebook: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis; David Z. D’Argenio Book 1991 Springer Science+Business Media New

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A Bayesian Kinetic Control Strategy for Cyclosporin in Renal Transplantationhild at the University of Minnesota Hospital in 1953. This issued in a life-saving advance, the use of which has expanded enormously to in­ clude treatment of many areas of cardiac disease. Not unexpectedly, surgical techniques allowed through the use of the heart-lung machine (open-heart surgery) c

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Property Groups and Property Types,perties of the gastrointestinal tract affect the extent and/or rate of oral drug absorption. Some of these factors include: ., solubility and dissolution rate, aqueous diffusivity, partition coefficient, chemical and enzymatic stability, intestinal ., transit time, gastrointestinal motility, endogen

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Property Groups and Property Types,tions of an endogenous or exogenous compound are practically identical, whether the blood sample is obtained from an arm artery, an arm vein, a leg vein, a pulmonary artery or a jugular vein. Such a sampling site-independent concept has apparently originated from an unrigorously tested assumption th

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Property Groups and Property Types,uctural model or a particular curve model. In view of the fact that interpretations of RTDs have been mostly based on compartmental models (e. g., [1, 2]), the following shortcomings of this class of structural models should be noted: 1) there is no . reason for the existence of homogeneous compartm

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Tables on Thermodynamic Properties,ing procedures and individualization of dosage regimen. Several methods have been developed to estimate the probability distribution of the pharmacokinetic parameters from measurements obtained in a sample of individuals. All these methods assume that parameters and covariates remain stationary with