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Titlebook: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis; David Z. D’Argenio Book 1991 Springer Science+Business Media New

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发表于 2025-3-21 20:07:12 | 显示全部楼层 |阅读模式
期刊全称Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
影响因子2023David Z. D’Argenio
视频videohttp://file.papertrans.cn/146/145951/145951.mp4
图书封面Titlebook: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis;  David Z. D’Argenio Book 1991 Springer Science+Business Media New
影响因子This volume records the proceedings of the Workshop on Advanced Meth­ ods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics and biomed­ ical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. It has been my experience that in many areas of biomedical research, when a meeting of this type is held, the general attitude of those experimentalists willing to attend is one of extreme skepticism: as a group they feel that mathematical modeling has little to offer them in furthering their understanding of the particular biological processes they are studying. This is certainly not the prevailing view when the topic is pharmacokinetics and drug response. Quite the contrary, the use of mathemati­ cal modeling and associated data analysis and computational meth
Pindex Book 1991
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发表于 2025-3-21 22:10:09 | 显示全部楼层
Binary Liquid Systems of Nonelectrolytes III) observed from relevant noxious stimuli to define clinical anesthetic depth. Finally, it is also possible to relate the EEG measure of anesthetic drug effect to the clinically-observed measures of anesthetic depth.
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Property Groups and Property Types,ach; 2) the definition of a sampling compartment from which elimination occurs does not allow for a differentiation between sampling upstream or downstream of the elimination site, which leads to inconsistencies in the definition of the volume of distribution, .. [3].
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Binary Liquid Systems of Nonelectrolytes IIIlinear dependance on clinically relevant concentrations of volatile anesthetics over a physiological range of temperatures. The probe has been tested in both gas and liquid phases, and should operate in blood and tissue, allowing development of a practical device for rapid . monitoring of general anesthetics.
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Binary Liquid Systems of Nonelectrolytes IIIct individual tissue drug concentrations, and to investigate alterations in physiological parameters on drug disposition. The advantages of PB-PK modeling are counterbalanced by variable parameter estimation methods, lack of uniform model discrimination methods and requirement of large data bases for either model development or validation.
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Property Groups and Property Types,use of the plasma (blood) or central compartment concept in multi-compartmental or noncompartmental analysis [8–12] in the last several decades has undoubtedly contributed to the general acceptance of the above assumption.
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Property Groups and Property Types,d an optimal sampling time of.where .. is the average population value of the elimination rate constant. These analyses generally utilize a localized linearization argument, which is strictly valid only in the limit as the population variance of the rate constant approaches zero.
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Property Groups and Property Types,les for maximal information. By varying the class of admissible controls, different strategies are generated. Control strategies to be discussed include: open loop, open loop feedback, separation principle, and iteration in policy space. Monte Carlo simulation studies of a terminal cost type problem are presented.
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