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Titlebook: Adjuvant Therapy of Primary Breast Cancer; Hans-Jörg Senn,Aron Goldhirsch,Bruno Osterwalder Conference proceedings 1989 Springer-Verlag Be

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期刊全称Adjuvant Therapy of Primary Breast Cancer
影响因子2023Hans-Jörg Senn,Aron Goldhirsch,Bruno Osterwalder
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学科分类Recent Results in Cancer Research
图书封面Titlebook: Adjuvant Therapy of Primary Breast Cancer;  Hans-Jörg Senn,Aron Goldhirsch,Bruno Osterwalder Conference proceedings 1989 Springer-Verlag Be
影响因子The ultimate "consumer" of the data presented at conferences on the primary treatment of operable breast cancer is the patient, and when, as in this disease, the benefits of therapy are relatively mod­ est, the availability and interpretation of the data from trials be­ comes an issue of primary importance. The effects of present treat­ ment are in fact such that more patients relapse despite therapy than are estimated to benefit from it. It is, therefore, extremely dif­ ficult for the physician to recommend unequivocally one particular adjuvant treatment modality for the vast population of women with breast cancer. The interpretation of results from clinical research-oriented pro­ grams is constantly applied, however, in the treatment of breast cancer patients outside of clinical trials. From presented or publish­ ed data, many physicians extrapolate indications for the use of a given treatment regimen for their patients, perceiving it as the "best available therapy. " It is essential that the "best available therapy" be selected individually for each patient. However, considering the modest effect of treatment upon outcome, it is imperative that those who provide the data - those
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Inference for Location Parameter,an enormous capacity to develop variant phenotypes which display altered degrees of drug sensitivity. (Goldie and Coldman 1984; Von Hoff 1985). Evidence is accumulating that many of the mechanisms of specific drug resistance that have been identified in experimental systems are also likely to occur in clinical situations (Fojo et al. 1987).
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Dirichlet and Polya tree process,ses, the thinking has changed to that of a two-component disease: local on the one hand, and generalized on the other, the latter being more critical the larger the tumor size, the faster the tumor growth rate, the greater the lymph node involvement, and the less the differentiation on histological or nuclear grading.
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https://doi.org/10.1007/978-3-642-83337-3adjuvant therapy; breast cancer; cancer; clinical trial; mortality; oncology; radiotherapy; Radiaton Oncolo
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978-3-642-83339-7Springer-Verlag Berlin Heidelberg 1989
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