| 期刊全称 | Acute Leukemias IV | | 期刊简称 | Prognostic Factors a | | 影响因子2023 | T. Büchner,W. Hiddemann,J. Ritter | | 视频video | | | 学科分类 | Haematology and Blood Transfusion‘ Hämatologie und Bluttransfusion | | 图书封面 |  | | 影响因子 | The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell bio | | Pindex | Conference proceedings 1994 |
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发表于 2025-3-21 17:35:36
