期刊全称 | A Systems Biology Approach to Blood | 影响因子2023 | Seth Joel Corey,Marek Kimmel,Joshua N. Leonard | 视频video | | 发行地址 | Informs readers how systems medicine may lead to new advances in blood pathophysiology and treatment.Overview of how blood and its diseases have provided an ideal model to study topics of stem cell bi | 学科分类 | Advances in Experimental Medicine and Biology | 图书封面 |  | 影响因子 | .The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels..A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best | Pindex | Book 2014 |
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