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Titlebook: A Systems Biology Approach to Blood; Seth Joel Corey,Marek Kimmel,Joshua N. Leonard Book 2014 The Editor(s) (if applicable) and The Author

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发表于 2025-3-21 16:17:55 | 显示全部楼层 |阅读模式
期刊全称A Systems Biology Approach to Blood
影响因子2023Seth Joel Corey,Marek Kimmel,Joshua N. Leonard
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发行地址Informs readers how systems medicine may lead to new advances in blood pathophysiology and treatment.Overview of how blood and its diseases have provided an ideal model to study topics of stem cell bi
学科分类Advances in Experimental Medicine and Biology
图书封面Titlebook: A Systems Biology Approach to Blood;  Seth Joel Corey,Marek Kimmel,Joshua N. Leonard Book 2014 The Editor(s) (if applicable) and The Author
影响因子.The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels..A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best
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发表于 2025-3-21 20:32:49 | 显示全部楼层
homocysteine concentrations are linked to various dietary, hormonal, and genetic variables, cancer development, and autoimmunity. Here in this chapter, we have explained detailed links about homocysteine and cancer. . is a sulfur-containing amino acid that is metabolized via one of the two pathways
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Systems Hematology: An Introductionlated proteins, human disease and life span.Covers descriptiExcess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patie
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Quantification and Modeling of Stem Cell–Niche Interactionondary topic.Homogeneous catalysis using transition metal complexes is an area of research that has grown enormously in recent years. Many amazing catalytic discoveries have been reported by researchers both in industry and in academia. .Homogeneous Catalysis: Understanding the Art. gives real insig
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Erythropoiesis: From Molecular Pathways to System Propertiesst straightforward way to affect the chemical behavior of a given metal ion is through changes in its ligands. It is well recognized that changes within the first coordination sphere of a metal ion can have a relatively dramatic impact on the properties of the entire complex. On the other hand, modi
发表于 2025-3-22 14:25:40 | 显示全部楼层
Systems Biology of Platelet–Vessel Wall Interactionsication throughout the chemical industry where they assist in the production of several million tonnes of chemicals each year. Since homogeneous systems, especially those incorporating transition metals, often function effectively under milder conditions than their heterogeneous counterparts, they a
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Systems Approach to Phagocyte Production and Activation: Neutrophils and Monocytesee, but a new buoyancy can fluctuate, as an active scalar. The case of stable stratification shows how gravity waves coexist with a vortex (toroidal) mode of motion. Experiments are presented, as well as models ranging from Reynolds Stress Models (e.g. Two-Component-Limit) to Rapid Distortion Theory
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Stochasticity and Determinism in Models of Hematopoiesisthe­ matical discipline. This theory has a lot of important applications in mechanics of composite and perforated materials, filtration, disperse media, and in many other branches of physics, mechanics and modern technology. There is a vast literature on the subject. The term averaging has been usua
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Systems Analysis of High-Throughput Dataly corrected by medical therapy, but AIH using the split-ejaculate method has been offered as a reasonable alternative because of its simplicity and potential benefit. The distribution of spermatozoa in the semen of animals and man is not uniform throughout the entire ejaculatory process. A historic
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Developing a Systems-Based Understanding of Hematopoietic Stem Cell Cycle Controls in cellular heredity are called . to emphasize their role in the somatic transmission of developmental (i.e. epigenetic) information and to distinguish them from rare, spontaneous mutations (Nanney 1958). Epigenetic changes are defined operationally as directed cell-heritable, phenotypic changes t
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