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Titlebook: Waldenström’s Macroglobulinemia; Véronique Leblond,Steve Treon,Meletios Dimoploulos Book 2017 Springer International Publishing Switzerlan

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书目名称Waldenström’s Macroglobulinemia
编辑Véronique Leblond,Steve Treon,Meletios Dimoploulos
视频video
概述Timely international book on this rare disease.Brings updates on clinical, biological and therapeutic data.Edited by the three world experts with contributions from high-profile authors, world leaders
图书封面Titlebook: Waldenström’s Macroglobulinemia;  Véronique Leblond,Steve Treon,Meletios Dimoploulos Book 2017 Springer International Publishing Switzerlan
描述.This book sheds new light on clinical, biological and therapeutic data on the rare disease Waldenström’s Macroglobulinemia (WM) with the participation of widely-recognized experts, involved in this field. It represents the efforts of physicians, scientists and patients, all around the world, to better understand and cure this rare disease..Considerable advances in the diagnosis, treatment indications, response criteria, prognostic factors and treatment options have been made since Dr Jan Waldenström first reported this “new syndrome“ 70 years ago. Particularly instrumental in advancing of our understanding of WM have been the eight international workshops devoted to this disease. New, exciting molecular data have recently been reported, allowing us to revisit the oncogenic events leading to WM B-cell proliferation and to use newly available compounds targeting oncogenic pathways..
出版日期Book 2017
关键词Chemotherapy; Chronic disease; Immunotherapy; Lymphoma; Monoclonal IgM; Orphan disease
版次1
doihttps://doi.org/10.1007/978-3-319-22584-5
isbn_softcover978-3-319-79413-6
isbn_ebook978-3-319-22584-5
copyrightSpringer International Publishing Switzerland 2017
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Waldenström Macroglobulinaemia: Pathological Features and Diagnostic Assessmentd in advances in diagnosis, prognostic assessment and post-treatment response evaluation. Similarly the demonstration of the MYD88 L265P mutation and its biologic effect has resulted in major therapeutic advances and improved survival outcomes for patients.
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Unusual Manifestations of IgM Monoclonal Gammopathiestion or even of a MGUS; the so-called “dangerous” small B-cell clone and monoclonal gammopathy of renal significance. This chapter describes IgM-related AL amyloidosis and the skin and kidney manifestations of IgM gammopathies, which are not uncommon and could in some cases involve other mechanisms than deposition or autoantibody activity.
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Genetic Predisposition to Waldenström Macroglobulinemiain providing both the basis and substrate for ongoing genetic studies aimed at identifying WM predisposition genes. Together, these investigations may help elucidate the host genetic factors underlying WM development and more broadly may provide insights into the aging immune system.
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Unusual Manifestations of IgM Monoclonal Gammopathiestion or even of a MGUS; the so-called “dangerous” small B-cell clone and monoclonal gammopathy of renal significance. This chapter describes IgM-related AL amyloidosis and the skin and kidney manifestations of IgM gammopathies, which are not uncommon and could in some cases involve other mechanisms than deposition or autoantibody activity.
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Epidemiology of Waldenström Macroglobulinemiah the median age of diagnosis is around 70 years. Known risk factors for WM include family history and chronic antigen stimulation (i.e. chronic infections and autoimmune diseases), and IgM MGUS, which can be thought of as an early state of WM. Over recent decades there have been evidence of increased survival over time.
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