Titlebook: 25 Years of p53 Research; Pierre Hainaut,Klas G. Wiman Book 2005 Springer Science+Business Media B.V. 2005 DNA.P53, Wiman, Hainaut, tumor

愤怒历史

Introduction to 3D Technologieson known as Li-Fraumeni syndrome1 is linked to germ-line mutation of the p53 gene (for a review see Varley et al., 1997), and by the clear tumour propensity shown by p53 knock-out mice (for a review see Venkatachalam and Donehower, 1998).

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https://doi.org/10.1007/978-3-031-01666-0ytotoxic therapies, for example, rely on the introduction of DNA damage or the inhibition of chromosome segregation. These lesions, when introduced at high levels, elicit a DNA damage response presumably distinct from any encountered during the early stages of tumor development.

暴发户

Lucia Knapčíková,Dragan Perakovićs among these observations were not apparent. Fifty years of research had demonstrated that viruses with both DNA and RNA genomes could cause cancer in animals. Over the next 45 years six new viruses were to be discovered that were able to initiate cancers in humans (Epstein-Barr Virus, Human T-Cell

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软膏

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Heterogeneous Buffering for 3D NoCsgnaling, stress response, cell cycle control, and apoptosis are a result of these . studies (Giaccia and Kastan, 1998; Ko and Prives, 1996; Levine, 1997; Vogelstein et al., 2000). However, a greater depth of understanding was facilitated by the advent first of transgenic mouse methodologies and then