Overview: Includes evolution of the adhesion-GPCR genes in several species.Explores how this proteolytic cleavage was identified as an intrinsic protein modification process in the majority adhesion-GPCRs.DescrUpon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses.
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