Titlebook: Adhesion‑GPCRs; Structure to Functio Simon Yona,Martin Stacey Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Baukonstruktion - vom Prinzip zum Detaileptors are expressed in the central nervous system (CNS), indicating their possible roles in the development and function of the CNS. Indeed, it has been shown that adhesion-GPCRs are involved in the regulation of neurulation, cortical development and neurite growth. Among the few adhesion-GPCRs bei

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https://doi.org/10.1007/978-3-662-64827-8s and extracellular matrix turn-over. Each of the steps is influenced by tumor cell interaction and interaction of the tumor cell with its microenvironment that consists of different cell types as tumor-associated fibroblasts, endothelial cells and leukocytes as well as the extracellular matrix prod

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https://doi.org/10.1007/978-3-663-09351-0a role in T-cell function. It was subsequently identified as a ligand for CD55, which has been previously identified as an innate regulator of complement. The interaction of this receptor-ligand pair has been shown to provide a potent costimulatory signal to human T cells, despite their modest affin

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Baukonstruktion – vom Prinzip zum Detailue structure containing a cleaved long extracellular domain (ECD) and a seven-transmembrane domain (7TM). In this chapter, we review previous reports which suggest G protein-dependent and -independent signaling pathways of adhesion-GPCRs and present our approach to investigate the signal transductio

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Baukonstruktion – vom Prinzip zum Detailmed for the ability of its extracellular region to inhibit angiogenesis in tumor models, its function in physiological contexts was elusive and remained an orphan receptor until recently..,.,.–. BAI1 is now considered a phagocytic receptor that can recognize phosphatidylserine exposed on apoptotic c

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Baukonstruktion – vom Prinzip zum Detailxpression, little is known about the function of this receptor family in male reproductive physiology. Insights into function are beginning to emerge with the increasing availability of genetically modified mice harbouring mutations in these genes. Gpr64 is the best characterised of the adhesion-GPC