Titlebook: Voltage-gated Sodium Channels: Structure, Function and Channelopathies; Mohamed Chahine Book 2018 Springer International Publishing AG, pa

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Mechanisms of Drug Binding to Voltage-Gated Sodium Channelsing, and cell-surface expression of the channels. The permeation pore of Na. channels is divided in two parts: the outer mouth of the pore is the site of the ion selectivity filter, while the inner cytoplasmic pore serves as the channel activation gate. The cytoplasmic lining of the permeation pore

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Effects of Benzothiazolamines on Voltage-Gated Sodium Channelsropensity to prolong the cardiac QT interval, due to hERG K. channel block. Lubeluzole very potently inhibits Na. channels in a voltage- and use-dependent manner, due to its great preferential affinity for inactivated channels and the presence of a protonable amine group. Patch-clamp experiments sug

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Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7f Nav1.7-selective inhibitors: the extracellular vestibule of the pore, the extracellular loops of voltage-sensor domain II (VSD2), and the extracellular loops of voltage-sensor domain IV (VSD4). Notably, these three receptor sites on Nav1.7 can all be defined as extracellular druggable sites, sugge

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Cardiac Arrhythmias Related to Sodium Channel Dysfunctionses, such as dilated cardiomyopathy. The same rare variants in . or related genes may present with different clinical phenotypes in different individuals and sometimes in members of the same family. Genetic background and epigenetic and environmental factors contribute to the expression of these ove

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d are identified in this introduction and are given attention throughout the text. The first and most classical approach uses a minimal set of Lagrangian genera978-3-642-52467-7978-3-642-52465-3Series ISSN 0258-1248

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Steven Molinarolo,Daniele Granata,Vincenzo Carnevale,Christopher A. Ahern

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Alessandro Farinato,Concetta Altamura,Jean-François Desaphy

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Voltage-gated Sodium Channels: Structure, Function and Channelopathies

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