| 书目名称 | Vitamin D and Cancer | | 编辑 | Donald L. Trump,Candace S. Johnson | | 视频video | http://file.papertrans.cn/984/983944/983944.mp4 | | 概述 | In view of the multiple biologic effects associated with vitamin D-based signaling and the potential for vitamin D-based approaches to provide a preventive or therapeutic approach to cancer, it is tim | | 图书封面 |  | | 描述 | .Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.. | | 出版日期 | Book 2011 | | 关键词 | Cancer; Cancer Research; Candace Johnson; D; Donald Trump; Vitamin D | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-7188-3 | | isbn_softcover | 978-1-4899-8264-3 | | isbn_ebook | 978-1-4419-7188-3 | | copyright | Springer Science+Business Media, LLC 2011 |
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