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Titlebook: Viral Cytopathology; Cellular Macromolecu Heinz Fraenkel-Conrat,Robert R. Wagner Book 1984 Plenum Press, New York 1984 biology.cytology.cyt

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Cytopathic Effects of Viruses: A General Survey,emphasis on the molecular events that ostensibly lead to cell death. After collecting several thousand references and spending 2 months merely drafting an outline, I realized the folly of such a herculean undertaking. Hence, this original single chapter has evolved into a full volume of chapters whi
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Transcription by RNA Polymerase II,wth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene. The enzyme of major interest in this regard is the eukaryotic DNA-dependent RNA polymerase (pol II), which
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Regulation of Eukaryotic Translation,alysis of the expression of eukaryotic gene sequences contained in plasmid vectors upon their introduction into eukaryotic cells, have provided a powerful and convenient tool to dissect this manner of control. Because the experimental design of studies of translational control is less straightforwar
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Picornavirus Inhibition of Host Cell Protein Synthesis,accompanied by increasing rates of viral protein synthesis, marked cytopathic effects, and ultimately cell death. In most cases, it is not known whether the “shut-off” of host cell protein synthesis results from an active process induced by the virus evolved for that (or some other) purpose, or whet
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Rhabdovirus Cytopathology: Effects on Cellular Macromolecular Synthesis,ts. The economic impact of the rhabdovirus diseases of plants and fish are quite considerable. The major diseases of mammals are vesicular stomatitis of cattle and swine with man as in incidental host and rabies, which affects domestic and wild mammals and is an ancient scourge of man. The rhabdovir
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Adenovirus Cytopathology,ls (Rowe ., 1953; Hilleman and Werner, 1954). The study of adenovirus productive infections, and transformation of rodent cells, has continually accelerated during the 30 years that have passed since these first descriptions. The application of ever more sophisticated molecular techniques has led to
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The Effects of Herpesviruses on Cellular Macromolecular Synthesis,ediate-early”) viral mRNA within 1–2 hr. This is soon followed by production of virus-specific proteins in a regulated sequence of stages (Honess and Roizman, 1974, 1975; Spear and Roizman, 1981). The α-mRNA is transcribed from the infecting genome by the cellular RNA polymerase II, which is normall
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Poxvirus Cytopathogenicity: Effects on Cellular Macromolecular Synthesis,ture made it possible to study these alterations at both the morphological and biochemical levels. Highly cytocidal viruses, during the process of either productive or abortive virus replication, ultimately kill the cell. Notable examples of this type of viruses are the picornaviruses, the rhabdovir
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